EFFECTS OF CARNOSINE AND RELATED COMPOUNDS ON THE STABILITY AND MORPHOLOGY OF ERYTHROCYTES FROM ALCOHOLICS

EFFECTS OF CARNOSINE AND RELATED COMPOUNDS ON THE STABILITY AND MORPHOLOGY OF ERYTHROCYTES FROM ALCOHOLICS

The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These beneficia...

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Veröffentlicht in:Alcohol and alcoholism (Oxford) 2000-01, Vol.35 (1), p.44-48
Hauptverfasser: Prokopieva, V. D., Bohan, N. A., Johnson, P., Abe, H., Boldyrev, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alcoholism
Alcoholism - blood
Alcoholism - drug therapy
Alkanesulfonic Acids - pharmacology
Anti-Ulcer Agents - pharmacology
Anti-Ulcer Agents - therapeutic use
Buffers
carnosine
Carnosine - analogs & derivatives
Carnosine - pharmacology
Carnosine - therapeutic use
Erythrocytes - drug effects
Erythrocytes - physiology
Hemolysis - drug effects
Hemolysis - physiology
Humans
Male
Middle Aged
Piperazines - pharmacology
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Zusammenfassung:The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These beneficial properties of the dipeptides do not appear to be directly related to their antioxidant or buffering properties.
ISSN:0735-0414
1464-3502
1464-3502
DOI:10.1093/alcalc/35.1.44