Case Report. Osteomyelitis caused by high resistant Candida guilliermondii

We describe a case of a 57‐year‐old patient with osteomyelitis at a finger of his right hand caused by Candida guilliermondii. The strains isolated were highly resistant to fluconazole and itraconazole. Using the three methods, microdilution, agardilation and E‐test, the highest minimum inhibitory concentrations (MICs) amounted to >256 μg ml−1 for fluconazole and >32 μg ml−1 for itraconazole. To our knowledge, this is the first time such high values have been described for C. guilliermondii. They correlated with the therapeutic non‐response to a triazole therapy in our patient. The patient was cured by partial amputation of the affected finger.