An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

An overview of the clinical application of antisense oligonucleotides for RNA-targeting therapies

Highlights • Recent human clinical trial data on RNAi approaches to gene down-regulation for genetic diseases. • Overview of current anti-microRNA drugs with specific emphasis on application to target Hepatitis C infection. • Update on the current state of ‘exon skipping’ field for both Duchenne mus...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in pharmacology 2015-10, Vol.24, p.52-58
Hauptverfasser: McClorey, Graham, Wood, Matthew J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Gene Expression
Humans
Internal Medicine
Medical Education
Oligonucleotides, Antisense - therapeutic use
RNA - genetics
RNA Splicing
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights • Recent human clinical trial data on RNAi approaches to gene down-regulation for genetic diseases. • Overview of current anti-microRNA drugs with specific emphasis on application to target Hepatitis C infection. • Update on the current state of ‘exon skipping’ field for both Duchenne muscular dystrophy and spinal muscular atrophy.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2015.07.005