Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment

Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment

Highlights • Effect of enriched environment on tooth loss-induced learning deficits is not known. • Enriched environment attenuated tooth loss-induced learning deficits. • Enriched environment prevented tooth loss-induced suppression of neurogenesis. • Enriched environment ameliorated tooth loss-ind...

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Veröffentlicht in:Archives of oral biology 2016-01, Vol.61, p.1-7
Hauptverfasser: Kondo, Hiroko, Kurahashi, Minori, Mori, Daisuke, Iinuma, Mitsuo, Tamura, Yasuo, Mizutani, Kenmei, Shimpo, Kan, Sonoda, Shigeru, Azuma, Kagaku, Kubo, Kin-ya
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Animals
Animals, Newborn
Brain-Derived Neurotrophic Factor - metabolism
Bromodeoxyuridine
Cell Differentiation
Cell Proliferation
Cell Survival
Dentistry
Enriched environment
Environment
Hippocampus
Hippocampus - cytology
Hippocampus - physiopathology
Immunohistochemistry
Learning ability
Male
Maze Learning
Mice
Molar
Neurogenesis
Phenotype
Spatial Memory
Tooth loss
Tooth Loss - physiopathology
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Zusammenfassung:Highlights • Effect of enriched environment on tooth loss-induced learning deficits is not known. • Enriched environment attenuated tooth loss-induced learning deficits. • Enriched environment prevented tooth loss-induced suppression of neurogenesis. • Enriched environment ameliorated tooth loss-induced suppression of BDNF expression. • Enriched environment ameliorated the risk of tooth loss-induced cognitive impairment.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.10.006