Production of high titer attenuated poliovirus strains on the serum-free PER.C6® cell culture platform for the generation of safe and affordable next generation IPV
Highlights • PER.C6® cells are susceptible to infection with attenuated poliovirus strains. • Sabin strains in PER.C6® cells show increased productivity as compared to Vero cells. • Sabin strain productivity in PER.C6® cells was maintained during infection at 10 l scale. • Rationally-attenuated stra...
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| Veröffentlicht in: | Vaccine 2015-11, Vol.33 (48), p.6611-6616 |
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| container_title | Vaccine |
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| creator | Sanders, Barbara P Oakes, Isabel de los Rios van Hoek, Vladimir Liu, Ying Marissen, Wilfred Minor, Philip D Wimmer, Eckard Schuitemaker, Hanneke Custers, Jerome H.H.V Macadam, Andrew Cello, Jeronimo Edo-Matas, Diana |
| description | Highlights • PER.C6® cells are susceptible to infection with attenuated poliovirus strains. • Sabin strains in PER.C6® cells show increased productivity as compared to Vero cells. • Sabin strain productivity in PER.C6® cells was maintained during infection at 10 l scale. • Rationally-attenuated strains demonstrated high yields on the PER.C6® platform. |
| doi_str_mv | 10.1016/j.vaccine.2015.10.091 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Allergy and Immunology Animals Antibodies, Viral - blood Cell Culture Techniques Cell Line Cercopithecus aethiops Culture Media, Serum-Free - chemistry Enzyme-Linked Immunosorbent Assay Manufacturing Mutation Next generation IPV PER.C6® cells Poliomyelitis Poliomyelitis - prevention & control Poliovirus Poliovirus - genetics Poliovirus - growth & development Poliovirus Vaccine, Inactivated - immunology Poliovirus Vaccine, Oral Rabbits Rationally-attenuated strains Sabin Vaccines Vaccines, Attenuated Vero Cells Viral Load Virus Cultivation - methods |
| title | Production of high titer attenuated poliovirus strains on the serum-free PER.C6® cell culture platform for the generation of safe and affordable next generation IPV |
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