Drastically lowering the titer of waterborne bacteriophage PRD1 by exposure to immobilized hydrophobic polycations

Decrease in the titer of bacteriophage PRD1 (a model of animal adenoviruses) in aqueous solutions caused by the presence of systematically chemically derivatized surfaces was kinetically investigated. The greatest loss of infectivity--up to a 4-log reduction in the titer--was observed with immobiliz...

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Veröffentlicht in:	Biotechnology letters 2004-11, Vol.26 (22), p.1695-1700
Hauptverfasser:	GELMAN, Faina, LEWIS, Kim, KLIBANOV, Alexander M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Aqueous solutions Bacteriophage PRD1 - drug effects Bacteriophage PRD1 - growth & development Biological and medical sciences Biotechnology Cell Count Cell Proliferation - drug effects Cell Survival - drug effects Fundamental and applied biological sciences. Psychology Hydrophobic and Hydrophilic Interactions Polyamines - pharmacology Polyethyleneimine - pharmacology Water Microbiology Water Pollution - prevention & control Water Purification - methods
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Beschreibung
Zusammenfassung:	Decrease in the titer of bacteriophage PRD1 (a model of animal adenoviruses) in aqueous solutions caused by the presence of systematically chemically derivatized surfaces was kinetically investigated. The greatest loss of infectivity--up to a 4-log reduction in the titer--was observed with immobilized hydrophobic polyethylenimine-based and dendrimer-based polycations.
ISSN:	0141-5492 1573-6776
DOI:	10.1007/s10529-004-3737-3