Understanding next generation sequencing in oncology: A guide for oncologists

Highlights • We explain common concepts and terminology used in next generation sequencing. • The process of DNA sequencing is summarised and different platforms compared. • The steps involved in analysing sequencing data are explained. • Potential applications and challenges of genetic sequencing a...

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Veröffentlicht in:	Critical reviews in oncology/hematology 2015-12, Vol.96 (3), p.463-474
Hauptverfasser:	Moorcraft, Sing Yu, Gonzalez, David, Walker, Brian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Biomarkers, Tumor - genetics Genetics Genomics - methods Hematology, Oncology and Palliative Medicine High-Throughput Nucleotide Sequencing - methods Humans Neoplasms - diagnosis Neoplasms - genetics Neoplasms - therapy Next generation sequencing NGS Practice Guidelines as Topic - standards
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Beschreibung
Zusammenfassung:	Highlights • We explain common concepts and terminology used in next generation sequencing. • The process of DNA sequencing is summarised and different platforms compared. • The steps involved in analysing sequencing data are explained. • Potential applications and challenges of genetic sequencing are discussed.
ISSN:	1040-8428 1879-0461
DOI:	10.1016/j.critrevonc.2015.06.007