Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice

Highlights • Spinal dorsal horn astrocytic Cx43 decreases following a peripheral nerve injury. • Reduction of Cx43 contributes to downregulation of GLT-1 in spinal dorsal horn. • Reduced Cx43 and GLT-1 expression increases glutamate neurotransmission. • Tumor necrosis factor downregulates both Cx43...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.293-310
Hauptverfasser:	Morioka, Norimitsu, Zhang, Fang Fang, Nakamura, Yoki, Kitamura, Tomoya, Hisaoka-Nakashima, Kazue, Nakata, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenovirus Allergy and Immunology Allodynia Animals Astrocytes Astrocytes - metabolism Connexin Connexin 43 - metabolism Down-Regulation Excitatory Amino Acid Transporter 2 - metabolism GLT-1 Glutamate Glutamic Acid - metabolism Hindlimb Ligation Male Mice Neuralgia - metabolism Neuropathic pain Partial sciatic nerve ligation Psychiatry Sciatic Nerve - surgery Spinal cord Spinal Cord Dorsal Horn - metabolism Synaptic Transmission Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • Spinal dorsal horn astrocytic Cx43 decreases following a peripheral nerve injury. • Reduction of Cx43 contributes to downregulation of GLT-1 in spinal dorsal horn. • Reduced Cx43 and GLT-1 expression increases glutamate neurotransmission. • Tumor necrosis factor downregulates both Cx43 and GLT-1 expression. • Restoring Cx43 by an adenovirus vector expressing Cx43 ameliorates neuropathic pain.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.06.015