A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept
Highlights • A novel vaccine concept for reducing negative immunomodulatory effects of PRRSV. • Vaccination with truncated ORF7 enhanced cellular immunity and viral clearance. • DNA vaccine reduced Tregs and enhances IFN-γ production following PRRSV infection. • Improving PRRSV-specific immunity is...
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| Veröffentlicht in: | Vaccine 2015-07, Vol.33 (32), p.3997-4003 |
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| container_end_page | 4003 |
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| container_issue | 32 |
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| container_title | Vaccine |
| container_volume | 33 |
| creator | Suradhat, Sanipa Wongyanin, Piya Kesdangsakonwut, Sawang Teankum, Komkrich Lumyai, Mongkol Triyarach, Sittikorn Thanawongnuwech, Roongroje |
| description | Highlights • A novel vaccine concept for reducing negative immunomodulatory effects of PRRSV. • Vaccination with truncated ORF7 enhanced cellular immunity and viral clearance. • DNA vaccine reduced Tregs and enhances IFN-γ production following PRRSV infection. • Improving PRRSV-specific immunity is possible by induction of CMI against N protein. |
| doi_str_mv | 10.1016/j.vaccine.2015.06.020 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 31, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-a3abc433abbf81579265638ac19a6baf8c6077789f4c6a59ce002d77506219d33</citedby><cites>FETCH-LOGICAL-c551t-a3abc433abbf81579265638ac19a6baf8c6077789f4c6a59ce002d77506219d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X15007975$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26079617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suradhat, Sanipa</creatorcontrib><creatorcontrib>Wongyanin, Piya</creatorcontrib><creatorcontrib>Kesdangsakonwut, Sawang</creatorcontrib><creatorcontrib>Teankum, Komkrich</creatorcontrib><creatorcontrib>Lumyai, Mongkol</creatorcontrib><creatorcontrib>Triyarach, Sittikorn</creatorcontrib><creatorcontrib>Thanawongnuwech, Roongroje</creatorcontrib><title>A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • A novel vaccine concept for reducing negative immunomodulatory effects of PRRSV. • Vaccination with truncated ORF7 enhanced cellular immunity and viral clearance. • DNA vaccine reduced Tregs and enhances IFN-γ production following PRRSV infection. • Improving PRRSV-specific immunity is possible by induction of CMI against N protein.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Bacterial infections</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA vaccine</subject><subject>Experiments</subject><subject>Hogs</subject><subject>Immune Tolerance</subject><subject>Immunization</subject><subject>Immunology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Nucleocapsid protein</subject><subject>Nucleocapsid Proteins - 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| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2015-07, Vol.33 (32), p.3997-4003 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animals Bacterial infections Cytokines Deoxyribonucleic acid DNA DNA vaccine Experiments Hogs Immune Tolerance Immunization Immunology Infections Infectious diseases Laboratories Lymphocytes Male Nucleocapsid protein Nucleocapsid Proteins - genetics Nucleocapsid Proteins - immunology Plasmids Porcine Reproductive and Respiratory Syndrome - immunology Porcine Reproductive and Respiratory Syndrome - pathology Porcine Reproductive and Respiratory Syndrome - prevention & control Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - immunology Proteins PRRSV Studies Swine Treatment Outcome Tregs Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology |
| title | A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept |
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