A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept

Highlights • A novel vaccine concept for reducing negative immunomodulatory effects of PRRSV. • Vaccination with truncated ORF7 enhanced cellular immunity and viral clearance. • DNA vaccine reduced Tregs and enhances IFN-γ production following PRRSV infection. • Improving PRRSV-specific immunity is...

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Veröffentlicht in:	Vaccine 2015-07, Vol.33 (32), p.3997-4003
Hauptverfasser:	Suradhat, Sanipa, Wongyanin, Piya, Kesdangsakonwut, Sawang, Teankum, Komkrich, Lumyai, Mongkol, Triyarach, Sittikorn, Thanawongnuwech, Roongroje
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Bacterial infections Cytokines Deoxyribonucleic acid DNA DNA vaccine Experiments Hogs Immune Tolerance Immunization Immunology Infections Infectious diseases Laboratories Lymphocytes Male Nucleocapsid protein Nucleocapsid Proteins - genetics Nucleocapsid Proteins - immunology Plasmids Porcine Reproductive and Respiratory Syndrome - immunology Porcine Reproductive and Respiratory Syndrome - pathology Porcine Reproductive and Respiratory Syndrome - prevention & control Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - immunology Proteins PRRSV Studies Swine Treatment Outcome Tregs Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology
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Zusammenfassung:	Highlights • A novel vaccine concept for reducing negative immunomodulatory effects of PRRSV. • Vaccination with truncated ORF7 enhanced cellular immunity and viral clearance. • DNA vaccine reduced Tregs and enhances IFN-γ production following PRRSV infection. • Improving PRRSV-specific immunity is possible by induction of CMI against N protein.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.06.020