Enhanced neutralising antibody response to bovine viral diarrhoea virus (BVDV) induced by DNA vaccination in calves
Highlights • Co-expression of a RIG-I agonist with BVDV viral antigen could enhance DNA vaccine potency in cattle. • Integration of RIG-I agonist greatly enhances BVDV neutralising antibody response. • BVDVE2 protein augments antibody response to NS3 in BVDV DNA vaccine.
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| Veröffentlicht in: | Vaccine 2015-07, Vol.33 (32), p.4004-4012 |
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| container_issue | 32 |
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| container_title | Vaccine |
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| creator | R. El-Attar, Laila M Thomas, Carole Luke, Jeremy A. Williams, James Brownlie, Joe |
| description | Highlights • Co-expression of a RIG-I agonist with BVDV viral antigen could enhance DNA vaccine potency in cattle. • Integration of RIG-I agonist greatly enhances BVDV neutralising antibody response. • BVDVE2 protein augments antibody response to NS3 in BVDV DNA vaccine. |
| doi_str_mv | 10.1016/j.vaccine.2015.06.017 |
| format | Article |
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| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2015-07, Vol.33 (32), p.4004-4012 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier); ProQuest Central |
| subjects | Allergy and Immunology Animals Antibiotics Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens Bovine viral diarrhea virus Bovine Virus Diarrhea-Mucosal Disease - prevention & control BVDV marker vaccine Cattle Deoxyribonucleic acid Diarrhea Viruses, Bovine Viral - genetics Diarrhea Viruses, Bovine Viral - immunology Disease Models, Animal DNA Flaviviridae Gene Expression Genetic Vectors Immune response Infections Injections, Intramuscular Ligands Peptide Hydrolases - genetics Peptide Hydrolases - immunology Plasmid DNA vaccine Plasmids Proteins RIG-I agonist RNA Helicases - genetics RNA Helicases - immunology RNA polymerase Sucrose Treatment Outcome Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral infections Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology |
| title | Enhanced neutralising antibody response to bovine viral diarrhoea virus (BVDV) induced by DNA vaccination in calves |
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