Enhanced neutralising antibody response to bovine viral diarrhoea virus (BVDV) induced by DNA vaccination in calves

Highlights • Co-expression of a RIG-I agonist with BVDV viral antigen could enhance DNA vaccine potency in cattle. • Integration of RIG-I agonist greatly enhances BVDV neutralising antibody response. • BVDVE2 protein augments antibody response to NS3 in BVDV DNA vaccine.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-07, Vol.33 (32), p.4004-4012
Hauptverfasser:	R. El-Attar, Laila M, Thomas, Carole, Luke, Jeremy, A. Williams, James, Brownlie, Joe
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibiotics Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens Bovine viral diarrhea virus Bovine Virus Diarrhea-Mucosal Disease - prevention & control BVDV marker vaccine Cattle Deoxyribonucleic acid Diarrhea Viruses, Bovine Viral - genetics Diarrhea Viruses, Bovine Viral - immunology Disease Models, Animal DNA Flaviviridae Gene Expression Genetic Vectors Immune response Infections Injections, Intramuscular Ligands Peptide Hydrolases - genetics Peptide Hydrolases - immunology Plasmid DNA vaccine Plasmids Proteins RIG-I agonist RNA Helicases - genetics RNA Helicases - immunology RNA polymerase Sucrose Treatment Outcome Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral infections Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Co-expression of a RIG-I agonist with BVDV viral antigen could enhance DNA vaccine potency in cattle. • Integration of RIG-I agonist greatly enhances BVDV neutralising antibody response. • BVDVE2 protein augments antibody response to NS3 in BVDV DNA vaccine.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.06.017