Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease

Highlights • The biological clock located in the suprachiasmatic nucleus dictates glucose metabolism. • Eating at the wrong time according to your biological clock puts you at risk of metabolic disease. • For optimal glucose homeostasis, non-photic and photic input to the suprachiasmatic nucleus should be aligned. • Serotonin from the raphe nuclei provides feedback to the SCN on eating and activity. • We propose a novel hypothesis in which serotonin is in the middle of chronodisruption and metabolic disorders.