Brain acetylcholine and choline concentrations and dynamics in a murine model of the Fragile X syndrome: Age, sex and region-specific changes

Highlights • Endogenous ACh and Ch contents and dynamics were assessed in FMR1KO mice and WT controls. • ACh concentration and synthesis were similar for both mice lines in all regions studied. • ACh synthesis, and Ch uptake from blood decreased with age in WT mice. • The age dependence of Ch uptake...

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Veröffentlicht in:	Neuroscience 2015-08, Vol.301, p.520-528
Hauptverfasser:	Scremin, O.U, Roch, M, Norman, K.M, Djazayeri, S, Liu, Y.-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholine - pharmacokinetics acetylcholine turnover Aging - physiology Animals Brain - drug effects Brain - metabolism Choline - metabolism Choline - pharmacokinetics cholinergic function Deuterium - pharmacokinetics Disease Models, Animal Female fmr1-KO mice Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X Syndrome - genetics Fragile X Syndrome - pathology GCMS Male Mice Mice, Transgenic Mutation - genetics Neurology Nonlinear Dynamics Sex Characteristics Time Factors
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Zusammenfassung:	Highlights • Endogenous ACh and Ch contents and dynamics were assessed in FMR1KO mice and WT controls. • ACh concentration and synthesis were similar for both mice lines in all regions studied. • ACh synthesis, and Ch uptake from blood decreased with age in WT mice. • The age dependence of Ch uptake from blood was absent in FMR1KO mice. • An increase in Ch uptake from blood was found in the cerebral cortex of FMR1KO female mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.06.036