Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease
Highlights • PCV13 and PPV23 were studied in Crohn's disease patients. • PCV13 induces higher serotype specific antibody response in Crohn's disease patients than PPV23. • Immunosuppressive drugs impaired the antibody response to PCV13 and PPV23. • TNF-α antagonist further impaired the res...
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| Veröffentlicht in: | Vaccine 2015-10, Vol.33 (41), p.5464-5469 |
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| container_issue | 41 |
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| container_title | Vaccine |
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| creator | Kantsø, Bjørn Halkjær, Sofie Ingdam Thomsen, Ole Østergaard Belard, Erika Gottschalck, Ida Benedikte Jørgensen, Charlotte Sværke Krogfelt, Karen A Slotved, Hans-Christian Ingels, Helene Petersen, Andreas Munk |
| description | Highlights • PCV13 and PPV23 were studied in Crohn's disease patients. • PCV13 induces higher serotype specific antibody response in Crohn's disease patients than PPV23. • Immunosuppressive drugs impaired the antibody response to PCV13 and PPV23. • TNF-α antagonist further impaired the response to PCV13 and PPV23. |
| doi_str_mv | 10.1016/j.vaccine.2015.08.011 |
| format | Article |
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blood</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antibody Formation - drug effects</subject><subject>Antibody Formation - immunology</subject><subject>Antibody response</subject><subject>Clinical trials</subject><subject>Crohn Disease - drug therapy</subject><subject>Crohn Disease - immunology</subject><subject>Crohn's disease</subject><subject>Drugs</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppressive agents</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Immunotherapy</subject><subject>Infectious diseases</subject><subject>Inflammatory bowel disease</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines - administration & dosage</subject><subject>Pneumococcal Vaccines - 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 13-Valent conjugated pneumococcal vaccine 23-Valent pneumococcal polysaccharide vaccine Adult Allergy and Immunology Antagonists Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibody Formation - drug effects Antibody Formation - immunology Antibody response Clinical trials Crohn Disease - drug therapy Crohn Disease - immunology Crohn's disease Drugs Female Humans Immunosuppressive agents Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Immunotherapy Infectious diseases Inflammatory bowel disease Male Medical research Medical treatment Middle Aged Patients Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - adverse effects Pneumococcal Vaccines - immunology Pneumococcus Pneumonia Polysaccharides, Bacterial - immunology Serotypes Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology Tumor Necrosis Factor-alpha - therapeutic use Tumor necrosis factor-TNF Tumor necrosis factor-α Vaccination Vaccines Vaccines, Conjugate |
| title | Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease |
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