Immunosuppressive drugs impairs antibody response of the polysaccharide and conjugated pneumococcal vaccines in patients with Crohn's disease

Highlights • PCV13 and PPV23 were studied in Crohn's disease patients. • PCV13 induces higher serotype specific antibody response in Crohn's disease patients than PPV23. • Immunosuppressive drugs impaired the antibody response to PCV13 and PPV23. • TNF-α antagonist further impaired the res...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-10, Vol.33 (41), p.5464-5469
Hauptverfasser:	Kantsø, Bjørn, Halkjær, Sofie Ingdam, Thomsen, Ole Østergaard, Belard, Erika, Gottschalck, Ida Benedikte, Jørgensen, Charlotte Sværke, Krogfelt, Karen A, Slotved, Hans-Christian, Ingels, Helene, Petersen, Andreas Munk
Format:	Artikel
Sprache:	eng
Schlagworte:	13-Valent conjugated pneumococcal vaccine 23-Valent pneumococcal polysaccharide vaccine Adult Allergy and Immunology Antagonists Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibody Formation - drug effects Antibody Formation - immunology Antibody response Clinical trials Crohn Disease - drug therapy Crohn Disease - immunology Crohn's disease Drugs Female Humans Immunosuppressive agents Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Immunotherapy Infectious diseases Inflammatory bowel disease Male Medical research Medical treatment Middle Aged Patients Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - adverse effects Pneumococcal Vaccines - immunology Pneumococcus Pneumonia Polysaccharides, Bacterial - immunology Serotypes Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology Tumor Necrosis Factor-alpha - therapeutic use Tumor necrosis factor-TNF Tumor necrosis factor-α Vaccination Vaccines Vaccines, Conjugate
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • PCV13 and PPV23 were studied in Crohn's disease patients. • PCV13 induces higher serotype specific antibody response in Crohn's disease patients than PPV23. • Immunosuppressive drugs impaired the antibody response to PCV13 and PPV23. • TNF-α antagonist further impaired the response to PCV13 and PPV23.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.08.011