Effects of environmental enrichment on behavioral deficits and alterations in hippocampal BDNF induced by prenatal exposure to morphine in juvenile rats

Highlights • Prenatal morphine induces deficits at both the behavioral and the biochemical levels. • A marked reversibility of deficits was found following environmental enrichment. • Environmental enrichment alleviates disorders produced by early insults.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-10, Vol.305, p.372-383
Hauptverfasser:	Ahmadalipour, A, Sadeghzadeh, J, Vafaei, A.A, Bandegi, A.R, Mohammadkhani, R, Rashidy-Pour, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Analgesics, Opioid - toxicity Analysis of Variance Animals anxiety Avoidance Learning - drug effects BDNF Brain-Derived Neurotrophic Factor - metabolism enriched environment Environment Female Gene Expression Regulation, Developmental - drug effects Hippocampus - metabolism Male Maze Learning memory Mental Disorders - metabolism Mental Disorders - nursing Mental Disorders - pathology Morphine - toxicity Neurology Pregnancy Prenatal Exposure Delayed Effects - physiopathology prenatal morphine Rats Rats, Wistar Swimming - psychology Time Factors
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Beschreibung
Zusammenfassung:	Highlights • Prenatal morphine induces deficits at both the behavioral and the biochemical levels. • A marked reversibility of deficits was found following environmental enrichment. • Environmental enrichment alleviates disorders produced by early insults.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.015