A Sense of Self: RIG-I’s Tolerance to Host RNA

The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downst...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-07, Vol.43 (1), p.1-2
1. Verfasser:	Schoggins, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DEAD-box RNA Helicases - genetics Humans Immune Tolerance - genetics Ligands RNA - genetics RNA Processing, Post-Transcriptional - genetics Studies Yellow fever virus - enzymology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner et al. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2015.06.022