Sensitivity of a rapid point of care assay for early HIV antibody detection is enhanced by its ability to detect HIV gp41 IgM antibodies
Highlights • The early sensitivity of INSTI is due to detection of HIV-1 IgM. This was shown by: • Providing evidence that INSTI gp41 antigen binds to HIV-1 IgM using HIV-IgM ELISA. • Providing evidence that INSTI protein-A based colour developer binds to human IgM. • Providing evidence that INSTI c...
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| Veröffentlicht in: | Journal of clinical virology 2015-10, Vol.71, p.67-72 |
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| container_title | Journal of clinical virology |
| container_volume | 71 |
| creator | Moshgabadi, Noushin Galli, Rick A Daly, Amelia C Ko, Sze Mun Shirley Westgard, Tayla E Bulpitt, Ashley F Shackleton, Christopher R |
| description | Highlights • The early sensitivity of INSTI is due to detection of HIV-1 IgM. This was shown by: • Providing evidence that INSTI gp41 antigen binds to HIV-1 IgM using HIV-IgM ELISA. • Providing evidence that INSTI protein-A based colour developer binds to human IgM. • Providing evidence that INSTI can detect anti-HIV IgM in early seroconversion samples. |
| doi_str_mv | 10.1016/j.jcv.2015.08.005 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1386-6532 |
| ispartof | Journal of clinical virology, 2015-10, Vol.71, p.67-72 |
| issn | 1386-6532 1873-5967 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Allergy and Immunology Anti-HIV-1 IgM antibody Early detection Early Diagnosis HIV Antibodies - blood HIV Envelope Protein gp41 - immunology HIV gp41 antigen HIV Infections - diagnosis Human immunodeficiency virus Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans IgM removal Immunoglobulin M - blood Infectious Disease INSTI Point-of-Care Systems Protein A Sensitivity and Specificity Serologic Tests - methods |
| title | Sensitivity of a rapid point of care assay for early HIV antibody detection is enhanced by its ability to detect HIV gp41 IgM antibodies |
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