Sensitivity of a rapid point of care assay for early HIV antibody detection is enhanced by its ability to detect HIV gp41 IgM antibodies

Highlights • The early sensitivity of INSTI is due to detection of HIV-1 IgM. This was shown by: • Providing evidence that INSTI gp41 antigen binds to HIV-1 IgM using HIV-IgM ELISA. • Providing evidence that INSTI protein-A based colour developer binds to human IgM. • Providing evidence that INSTI c...

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Veröffentlicht in:	Journal of clinical virology 2015-10, Vol.71, p.67-72
Hauptverfasser:	Moshgabadi, Noushin, Galli, Rick A, Daly, Amelia C, Ko, Sze Mun Shirley, Westgard, Tayla E, Bulpitt, Ashley F, Shackleton, Christopher R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anti-HIV-1 IgM antibody Early detection Early Diagnosis HIV Antibodies - blood HIV Envelope Protein gp41 - immunology HIV gp41 antigen HIV Infections - diagnosis Human immunodeficiency virus Human immunodeficiency virus 1 Human immunodeficiency virus 2 Humans IgM removal Immunoglobulin M - blood Infectious Disease INSTI Point-of-Care Systems Protein A Sensitivity and Specificity Serologic Tests - methods
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Beschreibung
Zusammenfassung:	Highlights • The early sensitivity of INSTI is due to detection of HIV-1 IgM. This was shown by: • Providing evidence that INSTI gp41 antigen binds to HIV-1 IgM using HIV-IgM ELISA. • Providing evidence that INSTI protein-A based colour developer binds to human IgM. • Providing evidence that INSTI can detect anti-HIV IgM in early seroconversion samples.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2015.08.005