Genetic diversity and population dynamics of Bordetella pertussis in China between 1950–2007

Highlights • A dynamic change in B. pertussis MTs over time in China. • The predominant MTs in Chinese recent isolates were different from other countries. • The ptxP1 remained predominant among Chinese B. pertussis isolates. • Temporal change of B. pertussis population may be related to the vaccina...

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Veröffentlicht in:	Vaccine 2015-11, Vol.33 (46), p.6327-6331
Hauptverfasser:	Xu, Yinghua, Zhang, Liu, Tan, Yajun, Wang, Lichan, Zhang, Shumin, Wang, Junzhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Bordetella pertussis Bordetella pertussis - classification Bordetella pertussis - genetics Bordetella pertussis - isolation & purification China China - epidemiology Developed countries Evolution Genetic diversity Genetic Variation Genotype Humans Infectious diseases Laboratories Minisatellite Repeats Molecular Typing Mortality Multilocus variable-number tandem repeats analysis Population Dynamics Public health Teenagers Toxins Vaccines Whooping cough Whooping Cough - epidemiology Whooping Cough - microbiology
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Beschreibung
Zusammenfassung:	Highlights • A dynamic change in B. pertussis MTs over time in China. • The predominant MTs in Chinese recent isolates were different from other countries. • The ptxP1 remained predominant among Chinese B. pertussis isolates. • Temporal change of B. pertussis population may be related to the vaccination.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.09.040