MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring

Highlights • Maternal MTHFR deficiency in mice resulted in short-term memory impairment in pups. • Reduced maternal dietary folate or choline also led to short-term memory impairment. • These deficiencies led to increased apoptosis and neurogenesis in the hippocampus of pups. • Reduced maternal dietary folate or choline altered hippocampal choline metabolism in pups.