Contribution and interaction of kinin receptors and dynorphin A in a model of trigeminal neuropathic pain in mice

Highlights • Interaction between kinin receptors and dynorphin A in orofacial neuropathic pain. • Dynorphin A (1–17) induces orofacial heat hyperalgesia. • Knockout mice for kinin receptor do not develop orofacial hyperalgesia. • Anti-dynorphin A antiserum blocked orofacial neuropathic pain....

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Veröffentlicht in:	Neuroscience 2015-08, Vol.300, p.189-200
Hauptverfasser:	Luiz, A.P, Schroeder, S.D, Rae, G.A, Calixto, J.B, Chichorro, J.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bradykinin - analogs & derivatives Bradykinin - metabolism Bradykinin - pharmacology Bradykinin B1 Receptor Antagonists - pharmacology Bradykinin B2 Receptor Antagonists - pharmacology Disease Models, Animal dynorphin A Dynorphins - metabolism Dynorphins - pharmacology Facial Pain - metabolism Hot Temperature Hyperalgesia - metabolism kinin Male Mice, Inbred C57BL Mice, Knockout Neuralgia - metabolism Neurology Neurotransmitter Agents - pharmacology orofacial hyperalgesia Pain Measurement Receptors, Bradykinin - genetics Receptors, Bradykinin - metabolism Touch trigeminal neuropathic pain
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Beschreibung
Zusammenfassung:	Highlights • Interaction between kinin receptors and dynorphin A in orofacial neuropathic pain. • Dynorphin A (1–17) induces orofacial heat hyperalgesia. • Knockout mice for kinin receptor do not develop orofacial hyperalgesia. • Anti-dynorphin A antiserum blocked orofacial neuropathic pain.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.05.015