A cyclophosphamide-sensitive cell compartment is essential for homologous protection conferred by licensed vaccines for the control of avian pathogenic Escherichia coli in chickens
Highlights • Vaccine-mediated protection of licensed APEC vaccines was analyzed in chickens. • Both vaccines induced significant IgY responses relative to controls. • Protection against homologous APEC challenge required a cyclophosphamide-sensitive cell population that includes B cells.
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| Veröffentlicht in: | Vaccine 2015-07, Vol.33 (31), p.3624-3627 |
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| container_end_page | 3627 |
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| container_issue | 31 |
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| container_title | Vaccine |
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| creator | Sadeyen, Jean-Rémy Kaiser, Pete Stevens, Mark P Dziva, Francis |
| description | Highlights • Vaccine-mediated protection of licensed APEC vaccines was analyzed in chickens. • Both vaccines induced significant IgY responses relative to controls. • Protection against homologous APEC challenge required a cyclophosphamide-sensitive cell population that includes B cells. |
| doi_str_mv | 10.1016/j.vaccine.2015.06.034 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2015-07, Vol.33 (31), p.3624-3627 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central |
| subjects | Allergy and Immunology Animals Antibodies, Bacterial - blood Antibody APEC B-Lymphocytes - immunology Bacterial Load Birds Bursectomy CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Chicken Chickens Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - toxicity E coli Escherichia coli Escherichia coli - immunology Escherichia coli Infections - immunology Escherichia coli Infections - pathology Escherichia coli Infections - prevention & control Escherichia coli Infections - veterinary Escherichia coli Vaccines - administration & dosage Escherichia coli Vaccines - immunology Flow cytometry Immunization Immunoglobulins Immunoglobulins - blood Infections Injections, Intramuscular Licenses Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Studies Vaccination Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology |
| title | A cyclophosphamide-sensitive cell compartment is essential for homologous protection conferred by licensed vaccines for the control of avian pathogenic Escherichia coli in chickens |
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