A cyclophosphamide-sensitive cell compartment is essential for homologous protection conferred by licensed vaccines for the control of avian pathogenic Escherichia coli in chickens

Highlights • Vaccine-mediated protection of licensed APEC vaccines was analyzed in chickens. • Both vaccines induced significant IgY responses relative to controls. • Protection against homologous APEC challenge required a cyclophosphamide-sensitive cell population that includes B cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-07, Vol.33 (31), p.3624-3627
Hauptverfasser:	Sadeyen, Jean-Rémy, Kaiser, Pete, Stevens, Mark P, Dziva, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Bacterial - blood Antibody APEC B-Lymphocytes - immunology Bacterial Load Birds Bursectomy CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Chicken Chickens Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - toxicity E coli Escherichia coli Escherichia coli - immunology Escherichia coli Infections - immunology Escherichia coli Infections - pathology Escherichia coli Infections - prevention & control Escherichia coli Infections - veterinary Escherichia coli Vaccines - administration & dosage Escherichia coli Vaccines - immunology Flow cytometry Immunization Immunoglobulins Immunoglobulins - blood Infections Injections, Intramuscular Licenses Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Studies Vaccination Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology
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Beschreibung
Zusammenfassung:	Highlights • Vaccine-mediated protection of licensed APEC vaccines was analyzed in chickens. • Both vaccines induced significant IgY responses relative to controls. • Protection against homologous APEC challenge required a cyclophosphamide-sensitive cell population that includes B cells.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.06.034