Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects
Highlights • Lyophilized MVA was more immunogenic than the current liquid formulation of MVA. • The lower ID dose of MVA was immunologically non-inferior to the standard SC dose. • The ID route resulted in more erythema and/or induration than the SC route. • The ID route may increase the number of a...
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| Veröffentlicht in: | Vaccine 2015-09, Vol.33 (39), p.5225-5234 |
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| container_title | Vaccine |
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| creator | Frey, Sharon E Wald, Anna Edupuganti, Srilatha Jackson, Lisa A Stapleton, Jack T Sahly, Hana El El-Kamary, Samer S Edwards, Kathryn Keyserling, Harry Winokur, Patricia Keitel, Wendy Hill, Heather Goll, Johannes B Anderson, Edwin L Graham, Irene L Johnston, Christine Mulligan, Mark Rouphael, Nadine Atmar, Robert Patel, Shital Chen, Wilbur Kotloff, Karen Creech, C. Buddy Chaplin, Paul Belshe, Robert B |
| description | Highlights • Lyophilized MVA was more immunogenic than the current liquid formulation of MVA. • The lower ID dose of MVA was immunologically non-inferior to the standard SC dose. • The ID route resulted in more erythema and/or induration than the SC route. • The ID route may increase the number of available doses in an emergency situation. |
| doi_str_mv | 10.1016/j.vaccine.2015.06.075 |
| format | Article |
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Buddy</creatorcontrib><creatorcontrib>Chaplin, Paul</creatorcontrib><creatorcontrib>Belshe, Robert B</creatorcontrib><title>Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • Lyophilized MVA was more immunogenic than the current liquid formulation of MVA. • The lower ID dose of MVA was immunologically non-inferior to the standard SC dose. • The ID route resulted in more erythema and/or induration than the SC route. • The ID route may increase the number of available doses in an emergency situation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Chemistry, Pharmaceutical</subject><subject>Confidence intervals</subject><subject>Discoloration</subject><subject>Drug-Related Side Effects and Adverse Reactions - epidemiology</subject><subject>Drug-Related Side Effects and Adverse Reactions - pathology</subject><subject>ELISA</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>IMVAMUNE</subject><subject>Injections, Intradermal</subject><subject>Injections, Subcutaneous</subject><subject>Intradermal</subject><subject>Lyophilized</subject><subject>Male</subject><subject>MVA</subject><subject>NCT00914732</subject><subject>Neutralization</subject><subject>Plaque reduction neutralizing antibody</subject><subject>Smallpox</subject><subject>Smallpox Vaccine - administration & dosage</subject><subject>Smallpox Vaccine - adverse effects</subject><subject>Smallpox Vaccine - immunology</subject><subject>Subcutaneous</subject><subject>Vaccines</subject><subject>Vaccinia-naïve</subject><subject>Variola</subject><subject>Young Adult</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks2O0zAUhSMEYsrAI4AssRkWCdd2EicbRlXFnzSIBT9iZ7n2jeqOE3fspFJ5KTa8AS-GQ8sgzYaVJfu75_jec7PsKYWCAq1fbou90toOWDCgVQF1AaK6ly1oI3jOKtrczxbA6jIvKXw7yx7FuAWAitP2YXbGalrymvJF9nPl-50KNvqB-I64g99trLPf0ZA9hjhF4uzNZA3pvbGdna__2FpFlsO1CopcfPi6fEE6H_rJqdH6IRI1GBKntZ5GNaBPGicpO4xBGQy9ciT4acQ4eyrTJ72YnubqBJENKjduDrdW-aB-_djjrLlFPcbH2YNOuYhPTud59uXN68-rd_nVx7fvV8urXFdtM-aiVYzylitlGCIvNW9RADBUoGuxNrUSvF2DAFMyw2lZ0nUngIPCrtHYIT_PLo66u-BvJoyj7G3U6NyxLUlFWTdNVXOR0Od30K2fwpB-lyjKGg6NoImqjpQOPsaAndwF26twkBTkHKvcylOsco5VQi1TrKnu2Ul9Wvdobqv-5piAyyOAaRx7i0FGbXHQaGxIE5PG2_9avLqjoF2avVbuGg8Y_3UjI5MgP827Na8WrSC1VjP-G0cv0LA</recordid><startdate>20150922</startdate><enddate>20150922</enddate><creator>Frey, Sharon E</creator><creator>Wald, Anna</creator><creator>Edupuganti, Srilatha</creator><creator>Jackson, Lisa A</creator><creator>Stapleton, Jack T</creator><creator>Sahly, Hana El</creator><creator>El-Kamary, Samer S</creator><creator>Edwards, Kathryn</creator><creator>Keyserling, Harry</creator><creator>Winokur, Patricia</creator><creator>Keitel, Wendy</creator><creator>Hill, Heather</creator><creator>Goll, Johannes B</creator><creator>Anderson, Edwin L</creator><creator>Graham, Irene L</creator><creator>Johnston, Christine</creator><creator>Mulligan, Mark</creator><creator>Rouphael, Nadine</creator><creator>Atmar, Robert</creator><creator>Patel, Shital</creator><creator>Chen, Wilbur</creator><creator>Kotloff, Karen</creator><creator>Creech, C. 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| ispartof | Vaccine, 2015-09, Vol.33 (39), p.5225-5234 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adolescent Adult Allergy and Immunology Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens Chemistry, Pharmaceutical Confidence intervals Discoloration Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology ELISA Female Heart attacks Humans Immunization Immunogenicity IMVAMUNE Injections, Intradermal Injections, Subcutaneous Intradermal Lyophilized Male MVA NCT00914732 Neutralization Plaque reduction neutralizing antibody Smallpox Smallpox Vaccine - administration & dosage Smallpox Vaccine - adverse effects Smallpox Vaccine - immunology Subcutaneous Vaccines Vaccinia-naïve Variola Young Adult |
| title | Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects |
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