Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects

Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects

Highlights • Lyophilized MVA was more immunogenic than the current liquid formulation of MVA. • The lower ID dose of MVA was immunologically non-inferior to the standard SC dose. • The ID route resulted in more erythema and/or induration than the SC route. • The ID route may increase the number of a...

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Veröffentlicht in:Vaccine 2015-09, Vol.33 (39), p.5225-5234
Hauptverfasser: Frey, Sharon E, Wald, Anna, Edupuganti, Srilatha, Jackson, Lisa A, Stapleton, Jack T, Sahly, Hana El, El-Kamary, Samer S, Edwards, Kathryn, Keyserling, Harry, Winokur, Patricia, Keitel, Wendy, Hill, Heather, Goll, Johannes B, Anderson, Edwin L, Graham, Irene L, Johnston, Christine, Mulligan, Mark, Rouphael, Nadine, Atmar, Robert, Patel, Shital, Chen, Wilbur, Kotloff, Karen, Creech, C. Buddy, Chaplin, Paul, Belshe, Robert B
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Allergy and Immunology
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antigens
Chemistry, Pharmaceutical
Confidence intervals
Discoloration
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - pathology
ELISA
Female
Heart attacks
Humans
Immunization
Immunogenicity
IMVAMUNE
Injections, Intradermal
Injections, Subcutaneous
Intradermal
Lyophilized
Male
MVA
NCT00914732
Neutralization
Plaque reduction neutralizing antibody
Smallpox
Smallpox Vaccine - administration & dosage
Smallpox Vaccine - adverse effects
Smallpox Vaccine - immunology
Subcutaneous
Vaccines
Vaccinia-naïve
Variola
Young Adult
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Zusammenfassung:Highlights • Lyophilized MVA was more immunogenic than the current liquid formulation of MVA. • The lower ID dose of MVA was immunologically non-inferior to the standard SC dose. • The ID route resulted in more erythema and/or induration than the SC route. • The ID route may increase the number of available doses in an emergency situation.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.06.075