Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells

Highlights • Low-level sodium arsenite inhibits TrxR activity in pancreatic cells. • Sodium arsenite accelerates ASK1 levels. • Sodium arsenite accelerates Bax/Bcl-2 ratio. • Arsenite-induced apoptosis is ASK1 dependent.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2015-09, Vol.40 (2), p.486-491
Hauptverfasser:	Yao, Xiao-Feng, Zheng, Bai-Lu, Bai, Jie, Jiang, Li-Ping, Zheng, Yue, Qi, Bao-Xu, Geng, Cheng-Yan, Zhong, Lai-Fu, Yang, Guang, Chen, Min, Liu, Xiao-Fang, Sun, Xian-Ce
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arsenites - pharmacology ASK1 Cell Line Cell Survival - drug effects Dose-Response Relationship, Drug Emergency Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects INS-1 cells Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects MAP Kinase Kinase Kinases - metabolism Oxidation-Reduction Rabbits Sodium arsenite Sodium Compounds - pharmacology Thioredoxin-Disulfide Reductase - metabolism TrxR
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Beschreibung
Zusammenfassung:	Highlights • Low-level sodium arsenite inhibits TrxR activity in pancreatic cells. • Sodium arsenite accelerates ASK1 levels. • Sodium arsenite accelerates Bax/Bcl-2 ratio. • Arsenite-induced apoptosis is ASK1 dependent.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.08.003