PDGFRβ+ cells in human and experimental neuro-vascular dysplasia and seizures

Highlights • Human FCD and TLE-HS display the highest PDGFRβ+ cells immunoreactivity, at the microvasculature identifying pericytes. • Parenchymal PDGFRβ / NG2 colocalization, but not IBA1, is observed in human brain tissues. • Pericyte-vascular dysplasia in MAM rat hippocampi corresponds to neurona...

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Veröffentlicht in:	Neuroscience 2015-10, Vol.306, p.18-27
Hauptverfasser:	Garbelli, R, de Bock, F, Medici, V, Rousset, M.C, Villani, F, Boussadia, B, Arango-Lievano, M, Jeanneteau, F, Daneman, R, Bartolomei, F, Marchi, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Cerebral Cortex - abnormalities Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebral Cortex - pathology Child Child, Preschool Disease Models, Animal DNA-Binding Proteins - metabolism Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology Hippocampus - blood supply Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Humans Infant Malformations of Cortical Development - complications Malformations of Cortical Development - metabolism Malformations of Cortical Development - pathology Malformations of Cortical Development - physiopathology neuro-vascular malformations Neurology PDGFRβ pericytes Pericytes - metabolism Pericytes - pathology Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta - metabolism seizures Seizures - complications Young Adult
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Zusammenfassung:	Highlights • Human FCD and TLE-HS display the highest PDGFRβ+ cells immunoreactivity, at the microvasculature identifying pericytes. • Parenchymal PDGFRβ / NG2 colocalization, but not IBA1, is observed in human brain tissues. • Pericyte-vascular dysplasia in MAM rat hippocampi corresponds to neuronal heterotopias. • Severe status epilepticus in rats is associated with a region-specific increase of PDGFRβ expression in MAM rats.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.07.090