EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1 and by inhibiting mutant p53

EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1 and by inhibiting mutant p53

Highlights • Enhancer of zeste homolog 2 (EZH2) is abnormally elevated in ovarian cancer. • EZH2 knockdown inhibited cell proliferation, colony formation, and cell invasion. • EZH2 knockdown increased the apoptotic pathway and p21waf1/cip1 expression. • Silencing of EZH2 inhibited mutant p53 protein...

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Veröffentlicht in:Cancer letters 2013-08, Vol.336 (1), p.53-60
Hauptverfasser: Seward, Shelly, Semaan, Assaad, Qazi, Aamer M, Gruzdyn, Oksana V, Chamala, Sreedhar, Bryant, Christopher C, Kumar, Sanjeev, Cameron, David, Sethi, Seema, Ali-Fehmi, Rouba, Morris, Robert, Bouwman, David L, Munkarah, Adnan R, Weaver, Donald W, Gruber, Scott A, Batchu, Ramesh B
Format: Artikel
Sprache:eng
Schlagworte:
Enhancer of zeste homolog 2 (EZH2)
Epithelial ovarian cancer (EOC)
Hematology, Oncology and Palliative Medicine
m p53
p21waf1/cip1
RNA interference (RNAi)
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Zusammenfassung:Highlights • Enhancer of zeste homolog 2 (EZH2) is abnormally elevated in ovarian cancer. • EZH2 knockdown inhibited cell proliferation, colony formation, and cell invasion. • EZH2 knockdown increased the apoptotic pathway and p21waf1/cip1 expression. • Silencing of EZH2 inhibited mutant p53 protein and tumor xenograft growth.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.04.012