RIFM fragrance ingredient safety assessment, ethyl anthranilate, CAS registry number 87-25-2

•Ethyl anthranilate safety assessment based on RIFM's criteria.•Safety assessment based on 7 Human health endpoints plus environmental.•Repeated dose toxicity was determined to give the most conservative systemic derived NO[A]EL.•An acceptable MOE was obtained.

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Bibliographische Detailangaben
Veröffentlicht in:	Food and chemical toxicology 2015-08, Vol.82, p.S97-S104
Hauptverfasser:	Api, A.M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M.L., Dekant, W., Fryer, A.D., Kromidas, L., La Cava, S., Lalko, J.F., Lapczynski, A., Liebler, D.C., Miyachi, Y., Politano, V.T., Ritacco, G., Salvito, D., Shen, J., Schultz, T.W., Sipes, I.G., Wall, B., Wilcox, D.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Consumer Product Safety DNA Damage - drug effects Dose-Response Relationship, Drug Endpoint Determination Humans Mice No-Observed-Adverse-Effect Level ortho-Aminobenzoates - chemistry ortho-Aminobenzoates - toxicity Perfume - chemistry Perfume - toxicity Rats Risk Assessment Toxicity Tests
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Beschreibung
Zusammenfassung:	•Ethyl anthranilate safety assessment based on RIFM's criteria.•Safety assessment based on 7 Human health endpoints plus environmental.•Repeated dose toxicity was determined to give the most conservative systemic derived NO[A]EL.•An acceptable MOE was obtained.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2015.03.017