Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients

Understanding the expression of proteins involved in DNA damage response could improve knowledge of the pathways that contribute to familial and sporadic breast cancer (BC). We aimed to assess the different roles of BRCA1, poly(ADP‐ribose) polymerase‐1 (PARP1), BRCT‐repeat inhibitor of hTERT express...

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Veröffentlicht in:International journal of cancer 2016-01, Vol.138 (1), p.110-120
Hauptverfasser: Partipilo, Giulia, Simone, Giovanni, Scattone, Anna, Scarpi, Emanuela, Azzariti, Amalia, Mangia, Anita
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Sprache:eng
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Zusammenfassung:Understanding the expression of proteins involved in DNA damage response could improve knowledge of the pathways that contribute to familial and sporadic breast cancer (BC). We aimed to assess the different roles of BRCA1, poly(ADP‐ribose) polymerase‐1 (PARP1), BRCT‐repeat inhibitor of hTERT expression (BRIT1) and novel SWItch 5 (SWI5) expression in 130 sporadic and 73 familial BC samples, by immunohistochemistry. In the sporadic group, negative nuclear BRCA1 (nBRCA1) expression was associated with positive PgR (p = 0.037). Negative association was found between nBRCA1 expression and HER2 (p = 0.001). In the familial group, nBRCA1 expression was associated with ER (p = 0.002). Reduced nBRCA1 expression was associated with higher histological grade and positive Ki67 both in sporadic (p = 0.0010, p = 0.047) and familial groups (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.29699