Fabrication of pseudo three-dimensional PADC cell culture substrates for dosimetric studies

Pseudo three-dimensional (3D) polyallyldiglycol carbonate (PADC) cell culture substrates were fabricated by creating micrometer-size pores on thin PADC films by alpha-particle irradiation and subsequent chemical etching. Our results showed comparatively fewer 53BP1 foci in alpha-particle irradiated...

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Veröffentlicht in:	Radiation measurements 2011-12, Vol.46 (12), p.1790-1794
Hauptverfasser:	Ng, C.K.M., Wong, M.Y.P., Lam, R.K.K., Ho, J.P.Y., Yu, K.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	53BP1 Alpha particles CR-39 Earth sciences Earth, ocean, space Exact sciences and technology Geochronology HeLa cells Isotope geochemistry. Geochronology PADC
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Pseudo three-dimensional (3D) polyallyldiglycol carbonate (PADC) cell culture substrates were fabricated by creating micrometer-size pores on thin PADC films by alpha-particle irradiation and subsequent chemical etching. Our results showed comparatively fewer 53BP1 foci in alpha-particle irradiated as well as bystander HeLa cells cultured on pseudo 3D PADC substrates than in those cultured on two-dimensional substrates.
ISSN:	1350-4487 1879-0925
DOI:	10.1016/j.radmeas.2011.06.009