Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats

Highlights • tPA increases chemokine MIP-1α expression and cerebral endothelial cell activation. • tPA increases MIP-1α expression in neurons and capillaries after stroke. • After stroke tPA induces microglia/macrophage recruitment and M1 polarization. • Progesterone attenuates tPA’s toxic effects i...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.267-279
Hauptverfasser:	Won, Soonmi, Lee, Jae-Kyung, Stein, Donald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anti-Inflammatory Agents - administration & dosage Cell Polarity - drug effects Chemokine CCL3 - metabolism Disease Models, Animal Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - physiopathology M1/M2 polarization Macrophage Macrophages - drug effects Macrophages - physiology Male Matrix Metalloproteinase 3 - metabolism Microglia Microglia - drug effects Microglia - physiology MIP-1α Neuroinflammation Progesterone Progesterone - administration & dosage Psychiatry Rats Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recovery Stroke Stroke - metabolism Stroke - physiopathology Tissue Plasminogen Activator - administration & dosage tPA
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Beschreibung
Zusammenfassung:	Highlights • tPA increases chemokine MIP-1α expression and cerebral endothelial cell activation. • tPA increases MIP-1α expression in neurons and capillaries after stroke. • After stroke tPA induces microglia/macrophage recruitment and M1 polarization. • Progesterone attenuates tPA’s toxic effects in brain endothelial cells and macrophages.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.06.007