Protective effect of edaravone against manganese-induced toxicity in cultured rat astrocytes

Highlights • Manganese (Mn) may lead to acute and/or chronic toxicity in human and animals. • Edaravone (EDA) is clinically used for treatment of patients with acute cerebral injury. • We tested whether EDA has protective effect against Mn toxicity in astrocyte cultures. • Mn dose-dependently reduce...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-09, Vol.40 (2), p.563-567
Hauptverfasser:	Evren, Vedat, Apaydin, Melda, Khalilnezhad, Asghar, Erbas, Oytun, Taskiran, Dilek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Antipyrine - analogs & derivatives Antipyrine - pharmacology Apoptosis Astrocyte Astrocytes - cytology Astrocytes - drug effects Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Edaravone Emergency Lipid Peroxidation - drug effects Manganese Manganese - toxicity Oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Toxicity
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Zusammenfassung:	Highlights • Manganese (Mn) may lead to acute and/or chronic toxicity in human and animals. • Edaravone (EDA) is clinically used for treatment of patients with acute cerebral injury. • We tested whether EDA has protective effect against Mn toxicity in astrocyte cultures. • Mn dose-dependently reduced cell viability and increased lipid peroxides in astrocyte cultures. • Treatment of astrocytes with EDA suppressed oxidative stress and cell death due to Mn exposure.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.08.010