Modifications of excitatory and inhibitory transmission in rat hippocampal pyramidal neurons by acute lithium treatment

Highlights • Acute effects of Li+ were examined in isolated rat hippocampal pyramidal neurons. • 30–150 mM Li+ inhibited glutamatergic eEPSCs and GABAergic eIPSCs. • The inhibition was greater in eEPSCs. • Li+ slightly inhibited exogenous glutamate and GABA responses. • Findings suggest a preferenti...

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Veröffentlicht in:	Brain research bulletin 2015-08, Vol.117, p.39-44
Hauptverfasser:	Wakita, Masahito, Nagami, Hideaki, Takase, Yuko, Nakanishi, Ryoji, Kotani, Naoki, Akaike, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Animals CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - physiology CA3 Region, Hippocampal - drug effects CA3 Region, Hippocampal - physiology Cells, Cultured Central Nervous System Agents - pharmacology Dose-Response Relationship, Drug eEPSC eIPSC Electric Stimulation Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Hippocampus Inhibitory Postsynaptic Potentials - drug effects Inhibitory Postsynaptic Potentials - physiology LiCl Lithium Compounds - pharmacology Neural Inhibition - drug effects Neural Inhibition - physiology Neurology Patch-Clamp Techniques Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Pyramidal Cells - drug effects Pyramidal Cells - physiology Rats, Wistar
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Zusammenfassung:	Highlights • Acute effects of Li+ were examined in isolated rat hippocampal pyramidal neurons. • 30–150 mM Li+ inhibited glutamatergic eEPSCs and GABAergic eIPSCs. • The inhibition was greater in eEPSCs. • Li+ slightly inhibited exogenous glutamate and GABA responses. • Findings suggest a preferential presynaptic inhibition by Li+.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.07.009