Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish ( Danio rerio )

Highlights • NPX effects rather expression of genes in intestine than liver in zebrafish. • Environmentally relevant concentration of NPX affects mRNA expression. • NPX causes up-regulation of CAT and GST mRNA expression. • NPX causes decrease of Ucp-2 gene expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2015-09, Vol.40 (2), p.343-348
Hauptverfasser:	Stancová, V, Ziková, A, Svobodová, Z, Kloas, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antioxidants - metabolism Catalase - genetics Danio rerio Emergency Fish Freshwater Gene Expression Regulation, Enzymologic - drug effects Glutathione Transferase - genetics Intestines - enzymology Ion Channels - genetics Liver - enzymology Mitochondrial Proteins - genetics mRNA expression Naproxen Naproxen - adverse effects Oxidative stress Uncoupling Protein 2 Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics
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Beschreibung
Zusammenfassung:	Highlights • NPX effects rather expression of genes in intestine than liver in zebrafish. • Environmentally relevant concentration of NPX affects mRNA expression. • NPX causes up-regulation of CAT and GST mRNA expression. • NPX causes decrease of Ucp-2 gene expression.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.07.009