Early Dengue Virus Infection in Human Skin: A Cycle of Inflammation and Infectivity

Early Dengue Virus Infection in Human Skin: A Cycle of Inflammation and Infectivity

Early events during dengue virus (DENV) infection remain poorly understood. In this issue, Schaeffer and colleagues employ ex vivo human skin cells to investigate viral infection. They show that skin-resident immune cells are infected by DENV and that their infectability is increased in the inflamma...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of investigative dermatology 2015-07, Vol.135 (7), p.1711-1712
Hauptverfasser: Ivory, Matthew O., Birchall, James C., Piguet, Vincent
Format: Artikel
Sprache:eng
Schlagworte:
Antigen-Presenting Cells - immunology
Dengue virus
Dengue Virus - pathogenicity
Epidermis - cytology
Humans
Interleukin-4 - metabolism
Skin Diseases, Viral - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Early events during dengue virus (DENV) infection remain poorly understood. In this issue, Schaeffer and colleagues employ ex vivo human skin cells to investigate viral infection. They show that skin-resident immune cells are infected by DENV and that their infectability is increased in the inflammatory skin conditions (especially those in which IL-4 is released) that accompany the mosquito bites transmitting the virus.
ISSN:0022-202X
1523-1747
DOI:10.1038/jid.2014.544