Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions

PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-11, Vol.160 (1), p.17-19
Hauptverfasser:	Dygai, A. M., Zhdanov, V. V., Miroshnichenko, L. A., Udut, E. V., Zyuz’kov, G. N., Khrichkova, T. Yu, Simanina, E. V., Sherstoboev, E. Yu, Stavrova, L. A., Chaikovskii, A. V., Burmina, Ya. V., Agafonov, V. I., Reikhart, D. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Chromones - pharmacology Erythropoiesis - drug effects Erythropoiesis - physiology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - physiology Flavonoids - pharmacology General Pathology and Pathophysiology Glycoproteins Hematopoietic Stem Cells - metabolism Imidazoles - pharmacology Immunomagnetic Separation Internal Medicine Laboratory Medicine Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Inbred C57BL Morpholines - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - physiology Pathology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology Signal Transduction - drug effects Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent bone marrow cells. Blockade of PI3K and p38 signaling pathways stimulated production of erythropoietin by cells that do not produce it constitutively.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-3087-2