Hepatic histological alterations and biochemical changes induced by sildenafil overdoses

Sildenafil is used for the treatment of erectile dysfunction and is helping millions of men around the world to achieve and maintain a long lasting erection. Fifty healthy male rabbits (Oryctolagus cuniculus) were used in the present study and exposed daily to sildenafil (0, 1, 3, 6, 9 mg/kg) for 5...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2015-11, Vol.28 (6), p.2119-2127
Hauptverfasser:	Jarrar, Bashir Mahmoud, Almansour, Mansour Ibrahim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Ducts - drug effects Bile Ducts - metabolism Bile Ducts - pathology Biomarkers - blood Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Drug Overdose Hyperplasia Kupffer Cells - drug effects Kupffer Cells - metabolism Kupffer Cells - pathology Liver - drug effects Liver - metabolism Liver - pathology Liver Function Tests Male Necrosis Phosphodiesterase 5 Inhibitors - toxicity Rabbits Risk Assessment Sildenafil Citrate - toxicity Time Factors Toxicity Tests
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Zusammenfassung:	Sildenafil is used for the treatment of erectile dysfunction and is helping millions of men around the world to achieve and maintain a long lasting erection. Fifty healthy male rabbits (Oryctolagus cuniculus) were used in the present study and exposed daily to sildenafil (0, 1, 3, 6, 9 mg/kg) for 5 days per week for 7 weeks to investigate the biochemical changes and alterations in the hepatic tissues induced by this drug overdosing. In comparison with respective control rabbits, sildenafil overdoses elevated significantly (p-value
ISSN:	1011-601X