Bovine milk lactoferrin modulates the proliferative lymphocyte response to phytohemagglutinin
Bovine milk lactoferrin (2 to 20 μg ml⁻¹) changed enhancement of [³H]thymidine incorporation by phytohemagglutinin-stimulated rat spleen lymphocytes into suppression as their lactoferrin-withdrawal incorporation increased to greater than 10 000 cpm culture⁻¹ under the present isotope-labeling condit...
Gespeichert in:
Veröffentlicht in: | Biotechnology letters 1999-12, Vol.21 (12), p.1083-1089 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Bovine milk lactoferrin (2 to 20 μg ml⁻¹) changed enhancement of [³H]thymidine incorporation by phytohemagglutinin-stimulated rat spleen lymphocytes into suppression as their lactoferrin-withdrawal incorporation increased to greater than 10 000 cpm culture⁻¹ under the present isotope-labeling conditions. The enhancement disappeared by 15-min delayed addition of lactoferrin after addition of lectin. There was no lactoferrin effect when the cells were stimulated with 12-O-tetradecanoylphorbol-13-acetate plus ionomycin. Thus, lactoferrin has a certain extracellular effect on lymphocyte proliferation in response to the lectin. |
---|---|
ISSN: | 0141-5492 1573-6776 |
DOI: | 10.1023/A:1005696508289 |