A mild and efficient method for large scale synthesis of 3-aminocoumarins and its further application for the preparation of 4-bromo-3-aminocoumarins

A mild and efficient method for large scale synthesis of 3-aminocoumarins and its further application for the preparation of 4-bromo-3-aminocoumarins

A wide variety of 3-aminocoumarins have been synthesized in large scale from the corresponding 3-acetamidocoumarins by regioselective cleavage of carbon–nitrogen bond using 70% sulfuric acid under reflux conditions. The synthesized 3-aminocoumarins were further brominated regioselectively at the 4-p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2014-08, Vol.55 (35), p.4869-4874
Hauptverfasser: Das, Deb K., Sarkar, Satavisha, Khan, Musawwer, Belal, Md, Khan, Abu T.
Format: Artikel
Sprache:eng
Schlagworte:
3-Acetamidocoumarins
3-Aminocoumarins
Bonding
Bromination
Cleavage
N-Acetylglycine
Salicylaldehydes
Sulfuric acid
Synthesis (chemistry)
Tetrahedrons
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A wide variety of 3-aminocoumarins have been synthesized in large scale from the corresponding 3-acetamidocoumarins by regioselective cleavage of carbon–nitrogen bond using 70% sulfuric acid under reflux conditions. The synthesized 3-aminocoumarins were further brominated regioselectively at the 4-position of 3-aminocoumarin using BDMS as brominating agent.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.07.035