Reversible DNA i-motif to hairpin switching induced by copper(II) cations

Reversible DNA i-motif to hairpin switching induced by copper(II) cations

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by ch...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (74), p.14099-14102
Hauptverfasser: Day, Henry Albert, Wright, Elisé Patricia, MacDonald, Colin John, Gates, Andrew James, Waller, Zoë Ann Ella
Format: Artikel
Sprache:eng
Schlagworte:
Cations
Chelation
Copper - chemistry
Deoxyribonucleic acid
DNA - chemistry
Edetic Acid - chemistry
EDTA
Hydrogen-Ion Concentration
Nanostructure
Nanotechnology - methods
Nucleic Acid Conformation
Nucleotide Motifs
Solutions
Switching
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Beschreibung
Zusammenfassung:i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Herein we describe how copper(II) cations can alter the conformation of i-motif DNA into an alternative hairpin structure which is reversible by chelation with EDTA.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05111h