Acid-mediated cyclizations of SEM-protected heterocyclic anilines and adjacent hydroxyls or enol-ethers

Acid-mediated cyclizations of SEM-protected heterocyclic anilines and adjacent hydroxyls or enol-ethers

Acid-mediated cyclizations of SEM-protected heterocyclic anilines and adjacent hydroxyls or enol ethers during SEM deprotection are reported. Strategies to suppress these side reactions and their potential synthetic utilities are also described.

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Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2013-11, Vol.54 (47), p.6373-6377
Hauptverfasser: Meng, Zhaoyang, Sun, Binyuan, Reddy, Panduranga Adulla, Siddiqui, M. Arshad
Format: Artikel
Sprache:eng
Schlagworte:
Acid-mediated cyclization
Aniline
Dihydrooxazine
Ethers
Piperidin-4-one
Scanning electron microscopy
SEM
Strategy
Tetrahedrons
Utilities
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Beschreibung
Zusammenfassung:Acid-mediated cyclizations of SEM-protected heterocyclic anilines and adjacent hydroxyls or enol ethers during SEM deprotection are reported. Strategies to suppress these side reactions and their potential synthetic utilities are also described.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.09.059