Copper on iron promoted one-pot synthesis of I2-aminoenones and 3,5-disubstituted pyrazoles

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to I2-aminoenones via reductive ring opening of isoxazole intermediates. The valuable I2-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.