Synthesis of I3-lactams via a domino Michael addition/cyclization reaction of vinyl selenone with substituted amides

Synthesis of I3-lactams via a domino Michael addition/cyclization reaction of vinyl selenone with substituted amides

A novel, simple, and flexible approach to I-,I--disubstituted I3-lactams via a domino Michael addition/cyclization process involving the phenyl vinyl selenone and I2-ketoamides, malonylamides, or I2-cyanoamides is reported. The reactions proceed in good to excellent yields under mild reaction condit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Tetrahedron letters 2013-12, Vol.54 (49), p.6755-6757
Hauptverfasser: Sternativo, Silvia, Battistelli, Benedetta, Bagnoli, Luana, Santi, Claudio, Testaferri, Lorenzo, Marini, Francesca
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Michael reaction
Phenyls
Synthesis (chemistry)
Tetrahedrons
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A novel, simple, and flexible approach to I-,I--disubstituted I3-lactams via a domino Michael addition/cyclization process involving the phenyl vinyl selenone and I2-ketoamides, malonylamides, or I2-cyanoamides is reported. The reactions proceed in good to excellent yields under mild reaction conditions.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2013.10.004