Towards the elaboration of new gold-based optical theranostics
Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell line...
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| Veröffentlicht in: | Dalton transactions : an international journal of inorganic chemistry 2015-03, Vol.44 (11), p.4874-4883 |
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| container_end_page | 4883 |
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| container_issue | 11 |
| container_start_page | 4874 |
| container_title | Dalton transactions : an international journal of inorganic chemistry |
| container_volume | 44 |
| creator | Doulain, Pierre-Emmanuel Decréau, Richard Racoeur, Cindy Goncalves, Victor Dubrez, Laurence Bettaieb, Ali Le Gendre, Pierre Denat, Franck Paul, Catherine Goze, Christine Bodio, Ewen |
| description | Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements. |
| doi_str_mv | 10.1039/c4dt02977a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-9226 |
| ispartof | Dalton transactions : an international journal of inorganic chemistry, 2015-03, Vol.44 (11), p.4874-4883 |
| issn | 1477-9226 1477-9234 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biological Transport Biotechnology Bombesin - metabolism Boron Compounds - chemistry Cancer Cell Line, Tumor Derivatives Fluorescence Glucose Gold - chemistry Humans Microscopy, Fluorescence Optical Imaging - methods Organometallic Compounds - chemistry Organometallic Compounds - metabolism Organometallic Compounds - therapeutic use Tethering Uptakes |
| title | Towards the elaboration of new gold-based optical theranostics |
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