Towards the elaboration of new gold-based optical theranostics

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell line...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2015-03, Vol.44 (11), p.4874-4883
Hauptverfasser:	Doulain, Pierre-Emmanuel, Decréau, Richard, Racoeur, Cindy, Goncalves, Victor, Dubrez, Laurence, Bettaieb, Ali, Le Gendre, Pierre, Denat, Franck, Paul, Catherine, Goze, Christine, Bodio, Ewen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Biotechnology Bombesin - metabolism Boron Compounds - chemistry Cancer Cell Line, Tumor Derivatives Fluorescence Glucose Gold - chemistry Humans Microscopy, Fluorescence Optical Imaging - methods Organometallic Compounds - chemistry Organometallic Compounds - metabolism Organometallic Compounds - therapeutic use Tethering Uptakes
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Beschreibung
Zusammenfassung:	Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.
ISSN:	1477-9226 1477-9234
DOI:	10.1039/c4dt02977a