A novel and green synthesis of kojic acid derivatives in ionic liquid [bmim]BF4

A novel and green synthesis of kojic acid derivatives in ionic liquid [bmim]BF4

A series of 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)-3-phenylpropanamide derivatives were synthesized efficiently by one-pot condensation of aromatic aldehydes, meldrum’s acid, allomaltol, and ammonium acetate in ionic liquid [bmim]BF4. The novel synthesis method offers the advantage of operationa...

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Veröffentlicht in:Tetrahedron letters 2013-12, Vol.54 (52), p.7147-7150
Hauptverfasser: Li, Yuling, Jiang, Qiushi, Wang, Kai, Du, Baixiang, Wang, Xiangshan
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Ammonium acetate
Condensing
Derivatives
Ionic liquid
Ionic liquids
Kojic acid derivatives
Multi-component reactions
Reaction time
Synthesis (chemistry)
Tetrahedrons
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Zusammenfassung:A series of 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)-3-phenylpropanamide derivatives were synthesized efficiently by one-pot condensation of aromatic aldehydes, meldrum’s acid, allomaltol, and ammonium acetate in ionic liquid [bmim]BF4. The novel synthesis method offers the advantage of operational simplicity, mild reaction conditions, short reaction time, higher yields, and environmental friendliness.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2013.10.099