Huisgen click cycloadditions from a copper(II)-tren precatalyst without external sacrificial reductant

The copper(II) complex [Cu(C186tren)](Br)2, 2, is an efficient precatalyst for the Huisgen ‘click’ cycloaddtion which can be used at low loading without the requirement of an external sacrificial reductant such as sodium ascorbate. EPR studies support the in situ reduction of 2 by the alkyne to gene...

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Veröffentlicht in:Tetrahedron letters 2012-03, Vol.53 (11), p.1417-1420
Hauptverfasser: Harmand, Lydie, Lescure, Marie-Hélène, Candelon, Nicolas, Duttine, Mathieu, Lastécouères, Dominique, Vincent, Jean-Marc
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Sprache:eng
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Zusammenfassung:The copper(II) complex [Cu(C186tren)](Br)2, 2, is an efficient precatalyst for the Huisgen ‘click’ cycloaddtion which can be used at low loading without the requirement of an external sacrificial reductant such as sodium ascorbate. EPR studies support the in situ reduction of 2 by the alkyne to generate a reactive copper(I) catalyst.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.01.035